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Escherichia coli and Klebsiella species:
These bacteria are major causes of urinary tract, gastrointestinal tract, and wound infections. They are becoming resistant to a growing number of antibiotic classes at the same time as the frequency of outbreaks is increasing. Failure to treat with the appropriate antibiotics during a recently documented K. pneumoniae outbreak increased the mortality rate from 14 percent to 64 percent. Both microbes tend to rapidly evolve resistance to new drugs, but few are available or under development. New therapies are badly needed. |
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